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5fbx

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(New page: '''Unreleased structure''' The entry 5fbx is ON HOLD Authors: Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edward...)
Current revision (06:45, 19 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5fbx is ON HOLD
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==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor==
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<StructureSection load='5fbx' size='340' side='right'caption='[[5fbx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [https://pdbe.org/5fbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [https://www.ebi.ac.uk/pdbsum/5fbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbx ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Authors: Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Dixon, D., Knapp, S.
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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Description: Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Nowak, R]]
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__TOC__
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[[Category: Fedorov, O]]
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</StructureSection>
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[[Category: Muller, S]]
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[[Category: Homo sapiens]]
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[[Category: Siejka, P]]
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[[Category: Large Structures]]
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[[Category: Knapp, S]]
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[[Category: Arrowsmith CH]]
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[[Category: Clark, P.G.K]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Brennan PE]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Clark PGK]]
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[[Category: Dixon, D]]
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[[Category: Dixon D]]
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[[Category: Von Delft, F]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A.M]]
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[[Category: Fedorov O]]
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[[Category: Tallant, C]]
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[[Category: Knapp S]]
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[[Category: Srikannathasan, V]]
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[[Category: Muller S]]
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[[Category: Nowak R]]
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[[Category: Siejka P]]
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[[Category: Srikannathasan V]]
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[[Category: Tallant C]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor

PDB ID 5fbx

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