m |
|
| (One intermediate revision not shown.) |
| Line 1: |
Line 1: |
| - | ==Monoclinic crystal form of pNOB8 AspA-DNA complex==
| + | #REDIRECT [[5k1y]] This PDB entry is obsolete and replaced by 5k1y |
| - | <StructureSection load='5fc0' size='340' side='right' caption='[[5fc0]], [[Resolution|resolution]] 2.97Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[5fc0]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FC0 FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fc0 OCA], [http://pdbe.org/5fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fc0 PDBsum]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | <div style="background-color:#fffaf0;">
| + | |
| - | == Publication Abstract from PubMed ==
| + | |
| - | Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms. Here, we unveil the machinery and assembly mechanism of the archaeal Sulfolobus pNOB8 partition system. This system uses three proteins: ParA; an atypical ParB adaptor; and a centromere-binding component, AspA. AspA utilizes a spreading mechanism to create a DNA superhelix onto which ParB assembles. This supercomplex links to the ParA motor, which contains a bacteria-like Walker motif. The C domain of ParB harbors structural similarity to CenpA, which dictates eukaryotic segregation. Thus, this archaeal system combines bacteria-like and eukarya-like components, which suggests the possible conservation of DNA segregation principles across the three domains of life.
| + | |
| - | | + | |
| - | Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.,Schumacher MA, Tonthat NK, Lee J, Rodriguez-Castaneda FA, Chinnam NB, Kalliomaa-Sanford AK, Ng IW, Barge MT, Shaw PL, Barilla D Science. 2015 Sep 4;349(6252):1120-4. doi: 10.1126/science.aaa9046. PMID:26339031<ref>PMID:26339031</ref>
| + | |
| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 5fc0" style="background-color:#fffaf0;"></div>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Schumacher, M A]]
| + | |
| - | [[Category: Archaea]]
| + | |
| - | [[Category: Cenpa]]
| + | |
| - | [[Category: Dna segregation]]
| + | |
| - | [[Category: Partition]]
| + | |
| - | [[Category: Pnob8]]
| + | |
| - | [[Category: Transcription-dna complex]]
| + | |
