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4xdx
From Proteopedia
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==The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris== | ==The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris== | ||
| - | <StructureSection load='4xdx' size='340' side='right' caption='[[4xdx]], [[Resolution|resolution]] 0.95Å' scene=''> | + | <StructureSection load='4xdx' size='340' side='right'caption='[[4xdx]], [[Resolution|resolution]] 0.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4xdx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDX OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4xdx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDX FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdx OCA], [https://pdbe.org/4xdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdx RCSB], [https://www.ebi.ac.uk/pdbsum/4xdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref> |
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| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Jakoncic JJ]] |
| - | [[Category: | + | [[Category: Ostrov DA]] |
| - | [[Category: | + | [[Category: Pompeu YA]] |
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Current revision
The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris
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