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Defensin

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<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene='50/509378/Cv/1'>
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<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene='50/509378/Cv/4'>
__TOC__
__TOC__
== Function ==
== Function ==
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== Relevance ==
== Relevance ==
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There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics.
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There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics<ref>PMID:2997278</ref>.
== Disease ==
== Disease ==
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Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients.
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Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients<ref>PMID:25265350</ref>.
== Structural highlights ==
== Structural highlights ==
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DEF contains <scene name='50/509378/Cv/2'>6-8 conserved cysteine residues</scene>.
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DEF contains <scene name='50/509378/Cv/5'>6-8 conserved cysteine residues</scene>.
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</StructureSection>
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==3D structures of defensin==
==3D structures of defensin==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Defensin 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*α-defensin
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</StructureSection>
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**[[1ica]] – DEFA – ''Protophormia terraenovae''<BR />
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**[[1ews]] – DEFA RK-1 – rabbit – NMR<BR />
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**[[2k1i]] - RmDEFA – Rhesus macaque - NMR<BR />
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**[[1zmh]], [[1zmi]], [[1zmk]] - hDEFA HNP-2 (mutant) – human<BR />
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**[[3gny]], [[3go0]], [[3hj2]] - hDEFA HNP-1<BR />
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**[[2kht]] - hDEFA HNP-1 - NMR<BR />
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**[[2pm1]], [[2pm4]], [[2pm5]], [[3hjd]], [[3h6c]], [[3lo1]], [[3lo2]], [[3lo4]], [[3lo6]], [[3lo8]], [[3loe]], [[3lvx]], [[4du0]], [[4lb1]], [[4lb7]], [[4lbb]], [[4lbf]] - hDEFA HNP-1 (mutant) <BR />
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**[[1zmm]] – hDEFA4 <BR />
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**[[2lew]] – mDEFA4 (mutant) – mouse – NMR<br />
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**[[2ley]] – mDEFA4 – NMR<br />
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**[[1zmp]] – hDEFA5<BR />
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**[[2lxz]] – hDEFA5 – NMR<br />
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**[[3i5w]], [[4e82]], [[4e83]], [[4e86]] – hDEFA5 (mutant) <BR />
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**[[1zmq]] – hDEFA6<BR />
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**[[3qte]] – hDEFA6 (mutant)
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*β-defensin
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**[[1iju]], [[1ijv]] – hDEFB1<BR />
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**[[2nlb]], [[2nld]], [[2nle]], [[2nlf]], [[2nlg]], [[2nlh]], [[2nlp]], [[2nlq]], [[2nls]], [[2plz]], [[2lwl]], [[2nlc]] - hDEFB1 (mutant) <BR />
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**[[1e4s]], [[1kj5]] – hDEFB1 – NMR<BR />
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**[[1fd3]], [[1fd4]] – hDEFB2 <BR />
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**[[1fqq]], [[1e4q]] - hDEFB2 – NMR<BR />
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**[[2lg5]] - cDEFB2 – chicken – NMR<BR />
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**[[2lg6]] - cDEFB2 (mutant) – NMR<BR />
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**[[1kj6]] – hDEFB3 – NMR<BR />
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**[[1e4t]] – mDEFB7 – NMR<BR />
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**[[1e4r]] - mDEFB8 – NMR<BR />
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**[[1bnb]] – DEFB12 – bovine – NMR<BR />
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*ϑ-defensin
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**[[1hvz]] – RmDEF1 – NMR<BR />
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*Other defensins
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**[[1dfn]] – hDEF HNP-3 <BR />
 
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**[[3lo9]] – hDEF1 (mutant)<br />
 
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**[[2mit]] – hDEF5 – NMR<br />
 
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**[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />
 
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**[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />
 
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**[[4aaz]], [[4ab0]] - tDEF NAD1<BR />
 
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**[[4cqk]] - tDEF NAD1 + ligand<br />
 
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**[[1ozz]] – AdDEF ARD1 – ''Archaeoprepona demophon'' – NMR<BR />
 
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**[[1p00]], [[1p0a]] - AdDEF ARD1 (mutant) – NMR<BR />
 
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**[[1ti5]] - VrDEF – ''Vigna radiata'' – NMR<BR />
 
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**[[2gl1]] – VrDEF2<BR />
 
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**[[2b68]] - DEF – Pacific oyster – NMR<BR />
 
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**[[2b5b]] - DEF – Loggerhead turtle – NMR<BR />
 
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**[[2e3e]], [[2e3f]], [[2e3g]], [[2ny8]], [[2ny9]], [[2nz3]] - DEF (mutant) – Anopheles – NMR<BR />
 
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**[[2rng]] - DEF – Horseshoe crab – NMR<BR />
 
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**[[3psm]] – DEF – Potato bean<BR />
 
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**[[2ksk]] – DEF5 – Sugarcane - NMR<BR />
 
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**[[2lj7]] – DEF – lentil – NMR<br />
 
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**[[2lr3]] – DEF – barrel medic – NMR<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human α-defensin 1 (PDB entry 2pm4)

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References

  1. ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769
  2. ↑ Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985 Oct;76(4):1427-35. PMID:2997278 doi:http://dx.doi.org/10.1172/JCI112120
  3. ↑ Zhuravel OV, Gerashchenko OL, Khetsuriani MR, Soldatkina MA, Pogrebnoy PV. Expression of human beta-defensins-1-4 in thyroid cancer cells and new insight on biologic activity of hBD-2 in vitro. Exp Oncol. 2014 Sep;36(3):174-8. PMID:25265350

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Michal Harel, Alexander Berchansky

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