1bax

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[[Image:1bax.gif|left|200px]]
 
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{{Structure
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==MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE==
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|PDB= 1bax |SIZE=350|CAPTION= <scene name='initialview01'>1bax</scene>
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<StructureSection load='1bax' size='340' side='right'caption='[[1bax]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1bax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mason-Pfizer_monkey_virus Mason-Pfizer monkey virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1at7 1at7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bax OCA], [https://pdbe.org/1bax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bax RCSB], [https://www.ebi.ac.uk/pdbsum/1bax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bax ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bax OCA], [http://www.ebi.ac.uk/pdbsum/1bax PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bax RCSB]</span>
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[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV] p10 is the matrix protein. P14 is the nucleocapsid protein. p27 is the capsid protein.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/1bax_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D retroviruses. In type B and D retroviruses, the Gag protein pre-assembles before association with the membrane, whereas in type C retroviruses (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma membrane, where the particle formation occurs. The N-terminal domain of Gag, the matrix protein (MA), plays a critical role in determining this morphogenic difference. We have determined the three-dimensional solution structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The protein contains four alpha-helices that are structurally similar to the known type C MA structures. This similarity implies possible common assembly units and membrane-binding mechanisms for type C and B/D retroviruses. In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bax ConSurf].
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1BAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_mason-pfizer_virus Simian mason-pfizer virus]. This structure supersedes the now removed PDB entry 1AT7. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly., Conte MR, Klikova M, Hunter E, Ruml T, Matthews S, EMBO J. 1997 Oct 1;16(19):5819-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9312040 9312040]
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[[Category: Large Structures]]
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[[Category: Simian mason-pfizer virus]]
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[[Category: Mason-Pfizer monkey virus]]
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[[Category: Single protein]]
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[[Category: Conte MR]]
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[[Category: Conte, M R.]]
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[[Category: Hunter E]]
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[[Category: Hunter, E.]]
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[[Category: Klikova M]]
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[[Category: Klikova, M.]]
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[[Category: Matthews S]]
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[[Category: Matthews, S.]]
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[[Category: Ruml T]]
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[[Category: Ruml, T.]]
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[[Category: core protein]]
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[[Category: matrix protein]]
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[[Category: myristylation]]
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[[Category: polyprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:57:11 2008''
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Current revision

MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE

PDB ID 1bax

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