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5fd9

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==X-ray Crystal Structure of ESCRT-III Snf7 core domain (conformation B)==
==X-ray Crystal Structure of ESCRT-III Snf7 core domain (conformation B)==
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<StructureSection load='5fd9' size='340' side='right' caption='[[5fd9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5fd9' size='340' side='right'caption='[[5fd9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fd9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FD9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fd9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FD9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fd7|5fd7]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fd9 OCA], [http://pdbe.org/5fd9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fd9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fd9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fd9 OCA], [https://pdbe.org/5fd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fd9 RCSB], [https://www.ebi.ac.uk/pdbsum/5fd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fd9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SNF7_YEAST SNF7_YEAST]] Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Appears to sequester MVB cargo. Recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles.<ref>PMID:11559748</ref> <ref>PMID:12194857</ref>
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[https://www.uniprot.org/uniprot/SNF7_YEAST SNF7_YEAST] Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Appears to sequester MVB cargo. Recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles.<ref>PMID:11559748</ref> <ref>PMID:12194857</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Borbat, P P]]
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[[Category: Large Structures]]
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[[Category: Buchkovich, N J]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Emr, S D]]
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[[Category: Borbat PP]]
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[[Category: Freed, J H]]
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[[Category: Buchkovich NJ]]
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[[Category: Fromme, J C]]
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[[Category: Emr SD]]
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[[Category: Henne, W M]]
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[[Category: Freed JH]]
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[[Category: Mao, Y]]
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[[Category: Fromme JC]]
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[[Category: Tang, S]]
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[[Category: Henne WM]]
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[[Category: Active]]
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[[Category: Mao Y]]
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[[Category: Core]]
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[[Category: Tang S]]
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[[Category: Escrt]]
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[[Category: Protein transport]]
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[[Category: Snf7]]
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Current revision

X-ray Crystal Structure of ESCRT-III Snf7 core domain (conformation B)

PDB ID 5fd9

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