5ffv
From Proteopedia
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==Crystal structure of the bromodomain of human BRPF1 in complex with H3K14ac histone peptide== | ==Crystal structure of the bromodomain of human BRPF1 in complex with H3K14ac histone peptide== | ||
| - | <StructureSection load='5ffv' size='340' side='right' caption='[[5ffv]], [[Resolution|resolution]] 1.30Å' scene=''> | + | <StructureSection load='5ffv' size='340' side='right'caption='[[5ffv]], [[Resolution|resolution]] 1.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ffv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FFV OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5ffv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FFV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ffv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ffv OCA], [https://pdbe.org/5ffv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ffv RCSB], [https://www.ebi.ac.uk/pdbsum/5ffv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ffv ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Peregrin|Peregrin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Edwards | + | [[Category: Bountra C]] |
| - | [[Category: Knapp | + | [[Category: Edwards AM]] |
| - | [[Category: Krojer | + | [[Category: Knapp S]] |
| - | [[Category: Nunez-Alonso | + | [[Category: Krojer T]] |
| - | [[Category: Savitsky | + | [[Category: Nunez-Alonso G]] |
| - | [[Category: Tallant | + | [[Category: Savitsky P]] |
| - | [[Category: | + | [[Category: Tallant C]] |
| - | + | [[Category: Von Delft F]] | |
| - | + | ||
Current revision
Crystal structure of the bromodomain of human BRPF1 in complex with H3K14ac histone peptide
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