This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Diphtheria toxin
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Structure of diphtheria toxin complex with adenylyl-UMP (PDB code [[1ddt]]).' scene='59/592684/Cv/4'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
| - | '''Diphtheria toxin''' (DT) is a toxin which is secreted by the bacteria causing diphtheria. DT catalyzes the transfer of NAD to a diphthamide residue in the elongation factor-2 and thus inhibiting protein synthesis.<ref>PMID:20040</ref> | + | '''Diphtheria toxin''' (DT) is a toxin which is secreted by the bacteria causing diphtheria. DT catalyzes the transfer of NAD to a diphthamide residue in the elongation factor-2 and thus inhibiting protein synthesis.<ref>PMID:20040</ref> See also [[Toxins]]. |
== Disease == | == Disease == | ||
| Line 15: | Line 15: | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='59/592684/Cv/ | + | <scene name='59/592684/Cv/17'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains. <scene name='59/592684/Cv/19'>DT active site</scene> is located in a cleft in the C domain.<ref>PMID:7833807</ref> Water molecules are shown as red spheres. The 2 monomers of DT interact by domain swapping to form a <scene name='59/592684/Cv/16'>compact, globular dimer structure</scene>. |
</StructureSection> | </StructureSection> | ||
| Line 25: | Line 25: | ||
*Diphtheria toxin | *Diphtheria toxin | ||
| - | **[[1sgk]], [[4ow6]] – CbDT – ''Corynebacterium diphtheriae''<br /> | + | **[[1sgk]], [[4ow6]], [[7k7b]], [[7k7c]], [[7k7d]], [[7k7e]] – CbDT – ''Corynebacterium diphtheriae''<br /> |
| - | **[[4ae0]] – CdDT (mutant)<br /> | + | **[[4ae0]], [[5i82]] – CdDT (mutant)<br /> |
*Diphtheria toxin complex | *Diphtheria toxin complex | ||
Current revision
| |||||||||||
3D structures of diphtheria toxin
Updated on 01-July-2021
References
- ↑ Pappenheimer AM Jr. Diphtheria toxin. Annu Rev Biochem. 1977;46:69-94. PMID:20040 doi:http://dx.doi.org/10.1146/annurev.bi.46.070177.000441
- ↑ Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807
