Diphtheria toxin repressor

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Current revision

Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry 1c0w)

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Updated on 24-February-2019

↑ Guedon E, Helmann JD. Origins of metal ion selectivity in the DtxR/MntR family of metalloregulators. Mol Microbiol. 2003 Apr;48(2):495-506. PMID:12675807
↑ Pohl E, Holmes RK, Hol WG. Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain. J Mol Biol. 1999 Sep 24;292(3):653-67. PMID:10497029 doi:10.1006/jmbi.1999.3073

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 == Structural highlights ==
-DtxR structure contains an <scene name='55/554905/Cv/2'>N-terminal domain</scene> which contains <scene name='55/554905/Cv/3'>DNA-binding domain (DBD) with a helix-turn-helix motif</scene>, dimerization and metal-binding residues. DtxR contains <scene name='55/554905/Cv/4'>2 metal binding sites</scene>. A C-terminal domain folds into SH3-like conformation.<ref>PMID:10497029</ref>
+DtxR structure contains an <scene name='55/554905/Cv/7'>N-terminal domain</scene> which contains <scene name='55/554905/Cv/8'>DNA-binding domain (DBD) with a helix-turn-helix motif</scene>, dimerization and metal-binding residues. DtxR contains <scene name='55/554905/Cv/9'>2 metal binding sites</scene>.
+*<scene name='55/554905/Cv/10'>First metal binding site</scene>.
+*<scene name='55/554905/Cv/11'>Second metal binding site</scene>.
+A C-terminal domain folds into SH3-like conformation.<ref>PMID:10497029</ref>
 </StructureSection>