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4x3v

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==Crystal structure of human ribonucleotide reductase 1 bound to inhibitor==
==Crystal structure of human ribonucleotide reductase 1 bound to inhibitor==
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<StructureSection load='4x3v' size='340' side='right' caption='[[4x3v]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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<StructureSection load='4x3v' size='340' side='right'caption='[[4x3v]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X3V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X3V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3X4:N~6~-{N-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ACETYL]-2-METHYL-D-ALANYL}-D-LYSINE'>3X4</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3X4:N~6~-{N-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ACETYL]-2-METHYL-D-ALANYL}-D-LYSINE'>3X4</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3v OCA], [http://pdbe.org/4x3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x3v RCSB], [http://www.ebi.ac.uk/pdbsum/4x3v PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3v OCA], [https://pdbe.org/4x3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x3v RCSB], [https://www.ebi.ac.uk/pdbsum/4x3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x3v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
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[https://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4x3v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4x3v" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Homo sapiens]]
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[[Category: Ahmad, M F]]
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[[Category: Large Structures]]
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[[Category: Alam, I]]
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[[Category: Ahmad MF]]
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[[Category: Dealwis, C G]]
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[[Category: Alam I]]
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[[Category: Complex]]
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[[Category: Dealwis CG]]
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[[Category: Enzyme]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Reducatse]]
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Current revision

Crystal structure of human ribonucleotide reductase 1 bound to inhibitor

PDB ID 4x3v

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