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5b22

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'''Unreleased structure'''
 
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The entry 5b22 is ON HOLD
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==Dimer structure of murine Nectin-3 D1D2==
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<StructureSection load='5b22' size='340' side='right'caption='[[5b22]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5b22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B22 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b22 OCA], [https://pdbe.org/5b22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b22 RCSB], [https://www.ebi.ac.uk/pdbsum/5b22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b22 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NECT3_MOUSE NECT3_MOUSE] Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.<ref>PMID:10744716</ref> <ref>PMID:11827984</ref> <ref>PMID:12121624</ref> <ref>PMID:12558799</ref> <ref>PMID:16128743</ref>
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Authors: Katsuki Takebe, Takeshi Sangawa, Takuya Katsutani, Hirotaka Narita, Mamoru Suzuki
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==See Also==
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
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Description: Dimer structure of murine Nectin-3 D1D2
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Katsuki Takebe, Takeshi Sangawa, Takuya Katsutani, Hirotaka Narita, Mamoru Suzuki]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Katsutani T]]
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[[Category: Narita H]]
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[[Category: Sangawa T]]
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[[Category: Suzuki M]]
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[[Category: Takebe K]]

Current revision

Dimer structure of murine Nectin-3 D1D2

PDB ID 5b22

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