Pertussis toxin

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{{STRUCTURE_1prt| PDB=1prt | SIZE=400| SCENE= |right|CAPTION=Pertussis toxin, [[1prt]] }}
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<StructureSection load='1prt' size='350' side='right' caption='Pertussis toxin (PDB entry [[1prt]])' scene=''>
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== Function ==
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'''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>. For additional details see [[Pertussis Toxin-ATP Complex]].<br />
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'''Pertactin''' is another toxin produced by ''Bordetella''. For details see [[P.69 Pertactin Structure and Function]].
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== Relevance ==
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PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>.
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</StructureSection>
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== 3D Structures of Pertussis toxin ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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'''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough. For additional details see [[Pertussis Toxin-ATP Complex]].<br />
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*Pertussis toxin
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Pertactin is another toxin produced by "Bordetella". For details see [[P.69 Pertactin Structure and Function]].
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**[[1prt]] – BpPT - ''Bordetella pertussis''<br />
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**[[1pto]] – BpPT + galactose<br />
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**[[1bcp]] – BpPT + ATP<br />
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**[[6ro0]] – BpPT 1,2,5 subunits + islet-activating protein S2 + islet-activating protein S3 + islet-activating protein S4<br />
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**[[7ski]] – BpPT subunit 1 + phenanthridine derivative<br />
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**[[7sky]] – BpPT subunit 1 + NAD<br />
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**[[7u6z]] – BpPT subunit 1 (mutant) + NAD<br />
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**[[7sne]] – BpPT subunit 1 + BaAD<br />
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**[[7skk]] – BpPT subunit 1 + ADPR + nicotinamide<br />
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== 3D Structures of Pertussis toxin ==
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*Pertussis-like toxin
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[[1prt]] – BpPT - ''Bordetella pertussis''<br />
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**[[4z9d]] – EcPLT subunit A (mutant) – ''Escherichia coli''<br />
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[[1pto]] – BpPT + galactose<br />
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**[[4z9c]] – EcPLT subunits A,B <br />
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[[1bcp]] – BpPT + ATP
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**[[7k7h]] – SaPLT subunits A,B + antibody – ''Salmonella enterica'' – Cryo EM<br />
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'''Pertactin'''
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*'''Pertactin'''
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[[1dab]] - BpPer<br />
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**[[1dab]] - BpPer<br />
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[[2iou]] - Per extracellular domain + major tropism determinant - ''Bordetella bronchiseptica''<br />
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**[[2iou]] - Per extracellular domain + major tropism determinant - ''Bordetella bronchiseptica''<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pertussis toxin (PDB entry 1prt)

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3D Structures of Pertussis toxin

Updated on 22-August-2023

References

  1. ↑ Carbonetti NH, Artamonova GV, Andreasen C, Bushar N. Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. Infect Immun. 2005 May;73(5):2698-703. PMID:15845471 doi:http://dx.doi.org/10.1128/IAI.73.5.2698-2703.2005
  2. ↑ Connelly CE, Sun Y, Carbonetti NH. Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. Infect Immun. 2012 Dec;80(12):4317-32. doi: 10.1128/IAI.00808-12. Epub 2012 Oct, 1. PMID:23027529 doi:http://dx.doi.org/10.1128/IAI.00808-12

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jonathan Tringali

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