5h9m

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m (Protected "5h9m" [edit=sysop:move=sysop])
Current revision (07:28, 9 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5h9m is ON HOLD
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==Crystal structure of siah2 SBD domain==
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<StructureSection load='5h9m' size='340' side='right'caption='[[5h9m]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H9M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.761&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [https://pdbe.org/5h9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [https://www.ebi.ac.uk/pdbsum/5h9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>
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Authors: Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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Description: Crystal structure of siah2 SBD domain
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Dong, A]]
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__TOC__
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[[Category: Walker, J.R]]
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</StructureSection>
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[[Category: Bountra, C]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Large Structures]]
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[[Category: Tong, Y]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A.M]]
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[[Category: Bountra C]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Dong A]]
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[[Category: Zhang, Q]]
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[[Category: Edwards AM]]
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[[Category: Tong Y]]
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[[Category: Walker JR]]
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[[Category: Zhang Q]]

Current revision

Crystal structure of siah2 SBD domain

PDB ID 5h9m

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