Dynactin
From Proteopedia
(Difference between revisions)
| (13 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='2hl5' size='350' side='right' scene='44/444636/Cv/1' caption='Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion [[2hl5]]'> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | ' | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| + | __TOC__ | ||
| + | == Function == | ||
| + | '''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.<ref>PMID:1836789</ref> See also [[CAP-Gly domain]]. | ||
| + | == Disease == | ||
| + | Mutant dynactin was found in motor neuron disease.<ref>PMID:12627231</ref> | ||
| + | == Structural highlights == | ||
| + | <scene name='44/444636/Cv/3'>Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1</scene> ([[2hl5]]).<ref>PMID:16949363</ref> | ||
== 3D Structures of Dynactin == | == 3D Structures of Dynactin == | ||
| + | [[Dynactin 3D structures]] | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | |||
| - | [[2coy]] - hDCTN subunit 1 CAP-Gly domain – human – NMR<br /> | ||
| - | [[3e2u]] – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1<br /> | ||
| - | [[2hkq]], [[2hl3]], [[1txq]] - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal<br /> | ||
| - | [[2hqh]] - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain<br /> | ||
| - | [[2hl5]], [[3tq7]] - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal<br /> | ||
| - | [[2m02]] - DCTN subunit 1 CAP-Gly domain – rat – NMR<br /> | ||
| - | [[3tv0]] - hDCTN subunit 6<br /> | ||
| - | [[5aft]] – pDCTN subunits 2,3,5,6 + actin-related protein + actin + capping protein – pig – CryoEM<br /> | ||
| - | [[5afu]] – pDCTN subunits 2,3,5,6 + dynein tail + capping protein – CryoEM<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
