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3vl6

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==3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580 MPa==
==3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580 MPa==
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<StructureSection load='3vl6' size='340' side='right' caption='[[3vl6]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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<StructureSection load='3vl6' size='340' side='right'caption='[[3vl6]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sheon Sheon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VL6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VL6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPM:3-ISOPROPYLMALIC+ACID'>IPM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vlz|3vlz]], [[3vl2|3vl2]], [[3vl3|3vl3]], [[3vl4|3vl4]], [[3vl7|3vl7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPM:3-ISOPROPYLMALIC+ACID'>IPM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">leuB, SO_4235 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211586 SHEON])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vl6 OCA], [https://pdbe.org/3vl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vl6 RCSB], [https://www.ebi.ac.uk/pdbsum/3vl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vl6 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vl6 OCA], [http://pdbe.org/3vl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/3vl6 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEU3_SHEON LEU3_SHEON]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
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[https://www.uniprot.org/uniprot/LEU3_SHEON LEU3_SHEON] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-isopropylmalate dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Sheon]]
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[[Category: Shewanella oneidensis MR-1]]
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[[Category: Nagae, T]]
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[[Category: Nagae T]]
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[[Category: Watanabe, N]]
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[[Category: Watanabe N]]
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[[Category: Dac]]
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[[Category: Diamond-anvil cell]]
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[[Category: High-pressure]]
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[[Category: Ipmdh]]
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[[Category: Oxidoreductase]]
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Current revision

3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580 MPa

PDB ID 3vl6

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