5fis

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==Exonuclease domain-containing 1 (Exd1) in the Gd bound conformation==
==Exonuclease domain-containing 1 (Exd1) in the Gd bound conformation==
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<StructureSection load='5fis' size='340' side='right' caption='[[5fis]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5fis' size='340' side='right'caption='[[5fis]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fis]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FIS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fiq|5fiq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fis OCA], [https://pdbe.org/5fis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fis RCSB], [https://www.ebi.ac.uk/pdbsum/5fis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fis ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fis OCA], [http://pdbe.org/5fis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fis RCSB], [http://www.ebi.ac.uk/pdbsum/5fis PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EXD1_BOMMO EXD1_BOMMO] RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.<ref>PMID:26669262</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fis" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fis" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Exonuclease 3D structures|Exonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, K M]]
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[[Category: Bombyx mori]]
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[[Category: Fauvarque, M O]]
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[[Category: Large Structures]]
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[[Category: Homolka, D]]
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[[Category: Chen KM]]
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[[Category: Janeiro, B K.Rodino]]
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[[Category: Fauvarque MO]]
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[[Category: McCarthy, A A]]
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[[Category: Homolka D]]
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[[Category: Pandey, R R]]
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[[Category: McCarthy AA]]
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[[Category: Pillai, R S]]
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[[Category: Pandey RR]]
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[[Category: Reuter, M]]
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[[Category: Pillai RS]]
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[[Category: Sachidanandam, R]]
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[[Category: Reuter M]]
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[[Category: Yang, Z]]
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[[Category: Rodino Janeiro BK]]
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[[Category: Dimer]]
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[[Category: Sachidanandam R]]
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[[Category: Exonuclease]]
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[[Category: Yang Z]]
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[[Category: Hydrolase]]
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[[Category: Pirna biogenesis]]
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[[Category: Rna binding]]
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Current revision

Exonuclease domain-containing 1 (Exd1) in the Gd bound conformation

PDB ID 5fis

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