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4xjm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound== | |
| + | <StructureSection load='4xjm' size='340' side='right'caption='[[4xjm]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4xjm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=41E:3-{1-[(5-ACETYLTHIOPHEN-2-YL)CARBONYL]PIPERIDIN-4-YL}-N-(3-METHOXYPHENYL)PROPANAMIDE'>41E</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjm OCA], [https://pdbe.org/4xjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xjm RCSB], [https://www.ebi.ac.uk/pdbsum/4xjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Aminotransferase 3D structures|Aminotransferase 3D structures]] | |
| - | + | *[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Dai | + | <references/> |
| - | [[Category: Finzel | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Dai R]] | ||
| + | [[Category: Finzel BC]] | ||
Current revision
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound
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