5h9l

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Current revision (07:28, 9 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5h9l is ON HOLD until Paper Publication
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==Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4==
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<StructureSection load='5h9l' size='340' side='right'caption='[[5h9l]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5h9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H9L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [https://pdbe.org/5h9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [https://www.ebi.ac.uk/pdbsum/5h9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7YT09_RHOPR Q7YT09_RHOPR]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Blood-feeding disease vectors mitigate the negative effects of hemostasis and inflammation through the binding of small-molecule agonists of these processes by salivary proteins. In this study, a lipocalin protein family member (LTBP1) from the saliva of Rhodnius prolixus, a vector of the pathogen Trypanosoma cruzi, is shown to sequester cysteinyl leukotrienes during feeding to inhibit immediate inflammatory responses. Calorimetric binding experiments showed that LTBP1 binds leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4) but not biogenic amines, adenosine diphosphate, or other eicosanoid compounds. Crystal structures of ligand-free LTBP1 and its complexes with LTC4 and LTD4 reveal a conformational change during binding that brings Tyr114 into close contact with the ligand. LTC4 is cleaved in the complex, leaving free glutathione and a C20 fatty acid. Chromatographic analysis of bound ligands showed only intact LTC4, suggesting that cleavage could be radiation-mediated.
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Authors: Andersen, J.F.
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Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.,Jablonka W, Pham V, Nardone G, Gittis A, Silva-Cardoso L, Atella GC, Ribeiro JM, Andersen JF ACS Chem Biol. 2016 May 12. PMID:27124118<ref>PMID:27124118</ref>
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Description: Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Andersen, J.F]]
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<div class="pdbe-citations 5h9l" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rhodnius prolixus]]
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[[Category: Andersen JF]]

Current revision

Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4

PDB ID 5h9l

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