5he3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Bovine GRK2 in complex with Gbetagamma subunits and CCG224411== | |
| + | <StructureSection load='5he3' size='340' side='right'caption='[[5he3]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5he3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HE3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FF1:(4~{S})-4-[3-[2-(2,6-DIMETHYLPHENYL)ETHYLCARBAMOYL]-4-FLUORANYL-PHENYL]-~{N}-(1~{H}-INDAZOL-5-YL)-6-METHYL-2-OXIDANYLIDENE-3,4-DIHYDRO-1~{H}-PYRIMIDINE-5-CARBOXAMIDE'>FF1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5he3 OCA], [https://pdbe.org/5he3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5he3 RCSB], [https://www.ebi.ac.uk/pdbsum/5he3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5he3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]] | |
| - | + | *[[Transducin 3D structures|Transducin 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Cato | + | </StructureSection> |
| - | [[Category: Tesmer | + | [[Category: Bos taurus]] |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cato MC]] | ||
| + | [[Category: Tesmer JJG]] | ||
Current revision
Bovine GRK2 in complex with Gbetagamma subunits and CCG224411
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