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5hem

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'''Unreleased structure'''
 
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The entry 5hem is ON HOLD
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==Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2==
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<StructureSection load='5hem' size='340' side='right'caption='[[5hem]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hem]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HEM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hem OCA], [https://pdbe.org/5hem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hem RCSB], [https://www.ebi.ac.uk/pdbsum/5hem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hem ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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Authors: Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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Description: Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Pasquo, A]]
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__TOC__
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[[Category: Lori, C]]
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</StructureSection>
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[[Category: Knapp, S]]
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[[Category: Homo sapiens]]
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[[Category: Chiaraluce, R]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Consalvi, V]]
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[[Category: Bountra C]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Chiaraluce R]]
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[[Category: Von Delft, F]]
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[[Category: Consalvi V]]
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[[Category: Edwards, A.M]]
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[[Category: Edwards AM]]
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[[Category: Newman, J.A]]
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[[Category: Knapp S]]
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[[Category: Tallant, C]]
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[[Category: Lori C]]
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[[Category: Newman JA]]
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[[Category: Pasquo A]]
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[[Category: Tallant C]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2

PDB ID 5hem

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OCA

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