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5hfk

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'''Unreleased structure'''
 
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The entry 5hfk is ON HOLD
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==CRYSTAL STRUCTURE OF A GLUTATHIONE S-TRANSFERASE PROTEIN FROM ESCHERICHIA COLI OCh 157:H7 STR. SAKAI (ECs3186, TARGET EFI-507414) WITH BOUND GLUTATHIONE==
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<StructureSection load='5hfk' size='340' side='right'caption='[[5hfk]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hfk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HFK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.551&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfk OCA], [https://pdbe.org/5hfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hfk RCSB], [https://www.ebi.ac.uk/pdbsum/5hfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YFCG_ECOLI YFCG_ECOLI] Exhibits a very robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Has also a low GSH-dependent hydroperoxidase activity toward cumene hydroperoxide, but does not reduce H(2)O(2), tert-butyl hydroperoxide, benzyl peroxide, or lauroyl peroxide. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity using glutathionylspermidine (GspSH) as the nucleophilic substrate. Is involved in defense against oxidative stress, probably via its peroxidase activity.<ref>PMID:17018556</ref> <ref>PMID:19537707</ref>
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Authors: Himmel, D.M., Toro, R, Al Obaidi, N.F., Morisco, L.L., Wasserman, S.R., Stead, M., Attonito, J.D., Scott Glenn, A., Chamala, S., Chowdhury, S., Lafleur, J., Evans, B., Hillerich, B., Love, J., Seidel, R.D., Whalen, K.L., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative (EFI)
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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Description: CRYSTAL STRUCTURE OF A GLUTATHIONE S-TRANSFERASE PROTEIN FROM ESCHERICHIA COLI OCh 157:H7 STR. SAKAI (ECs3186, TARGET EFI-507414) WITH BOUND GLUTATHIONE
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Enzyme Function Initiative (Efi)]]
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__TOC__
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[[Category: Morisco, L.L]]
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</StructureSection>
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[[Category: Almo, S.C]]
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[[Category: Escherichia coli K-12]]
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[[Category: Attonito, J.D]]
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[[Category: Large Structures]]
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[[Category: Lafleur, J]]
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[[Category: Al Obaidi NF]]
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[[Category: Love, J]]
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[[Category: Almo SC]]
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[[Category: Wasserman, S.R]]
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[[Category: Attonito JD]]
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[[Category: Chowdhury, S]]
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[[Category: Chamala S]]
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[[Category: Gerlt, J.A]]
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[[Category: Chowdhury S]]
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[[Category: Stead, M]]
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[[Category: Evans B]]
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[[Category: Seidel, R.D]]
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[[Category: Gerlt JA]]
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[[Category: Hillerich, B]]
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[[Category: Hillerich B]]
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[[Category: Whalen, K.L]]
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[[Category: Himmel DM]]
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[[Category: Chamala, S]]
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[[Category: Lafleur J]]
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[[Category: Himmel, D.M]]
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[[Category: Love J]]
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[[Category: Scott Glenn, A]]
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[[Category: Morisco LL]]
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[[Category: Toro, R, Al Obaidi, N.F]]
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[[Category: Scott Glenn A]]
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[[Category: Evans, B]]
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[[Category: Seidel RD]]
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[[Category: Stead M]]
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[[Category: Toro R]]
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[[Category: Wasserman SR]]
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[[Category: Whalen KL]]

Current revision

CRYSTAL STRUCTURE OF A GLUTATHIONE S-TRANSFERASE PROTEIN FROM ESCHERICHIA COLI OCh 157:H7 STR. SAKAI (ECs3186, TARGET EFI-507414) WITH BOUND GLUTATHIONE

PDB ID 5hfk

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