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5dv7

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==Crystal Structure of NF90 tandem dsRBDs with dsRNA==
==Crystal Structure of NF90 tandem dsRBDs with dsRNA==
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<StructureSection load='5dv7' size='340' side='right' caption='[[5dv7]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='5dv7' size='340' side='right'caption='[[5dv7]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dv7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DV7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dv7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DV7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dv7 OCA], [http://pdbe.org/5dv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dv7 RCSB], [http://www.ebi.ac.uk/pdbsum/5dv7 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dv7 OCA], [https://pdbe.org/5dv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dv7 RCSB], [https://www.ebi.ac.uk/pdbsum/5dv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dv7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ILF3_MOUSE ILF3_MOUSE]] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity).
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[https://www.uniprot.org/uniprot/ILF3_MOUSE ILF3_MOUSE] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cook, A G]]
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[[Category: Large Structures]]
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[[Category: Grey, H]]
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[[Category: Mus musculus]]
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[[Category: Jayachandran, U]]
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[[Category: Synthetic construct]]
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[[Category: Double stranded rna binding domain]]
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[[Category: Cook AG]]
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[[Category: Drbp76]]
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[[Category: Grey H]]
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[[Category: Dsrbd]]
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[[Category: Jayachandran U]]
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[[Category: Dsrm]]
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[[Category: Dsrna]]
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[[Category: Ilf3]]
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[[Category: Nf90]]
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[[Category: Rna binding protein]]
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Current revision

Crystal Structure of NF90 tandem dsRBDs with dsRNA

PDB ID 5dv7

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