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1bn9

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[[Image:1bn9.gif|left|200px]]
 
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{{Structure
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==RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA==
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|PDB= 1bn9 |SIZE=350|CAPTION= <scene name='initialview01'>1bn9</scene>
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<StructureSection load='1bn9' size='340' side='right'caption='[[1bn9]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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<table><tr><td colspan='2'>[[1bn9]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BN9 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn9 OCA], [https://pdbe.org/1bn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bn9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bn9 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn9 OCA], [http://www.ebi.ac.uk/pdbsum/1bn9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bn9 RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA'''
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==Overview==
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Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes.
Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes.
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==About this Structure==
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Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*.,Castagne C, Terenzi H, Zakin MM, Delepierre M Biochimie. 2000 Aug;82(8):739-48. PMID:11018291<ref>PMID:11018291</ref>
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1BN9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN9 OCA].
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==Reference==
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Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11018291 11018291]
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[[Category: Protein complex]]
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[[Category: Castagne, C.]]
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[[Category: Delepierre, M.]]
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[[Category: Terenzi, H.]]
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[[Category: Zakin, M M.]]
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[[Category: dna]]
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[[Category: orphan nuclear receptor]]
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[[Category: response element]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:04:26 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1bn9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Castagne C]]
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[[Category: Delepierre M]]
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[[Category: Terenzi H]]
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[[Category: Zakin MM]]

Current revision

RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA

PDB ID 1bn9

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