5hle
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5hle is ON HOLD Authors: Nitta, R. Description: Category: Unreleased Structures Category: Nitta, R) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the ADP state== | |
| - | + | <StructureSection load='5hle' size='340' side='right'caption='[[5hle]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hle]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HLE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: Nitta | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hle OCA], [https://pdbe.org/5hle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hle RCSB], [https://www.ebi.ac.uk/pdbsum/5hle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hle ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCD_DROME NCD_DROME] NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule's minus end.<ref>PMID:2146510</ref> [https://www.uniprot.org/uniprot/KIF5C_RAT KIF5C_RAT] Microtubule-associated force-producing protein that may play a role in organelle transport (By similarity). Has ATPase activity (PubMed:27452403). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431).[UniProtKB:O60282][UniProtKB:P28738]<ref>PMID:23576431</ref> <ref>PMID:27452403</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Nitta R]] | ||
Current revision
Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the ADP state
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