4ynk

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==Crystal structure of vitamin D receptor ligand binding domain complexed with a 19-norvitamin D compound==
==Crystal structure of vitamin D receptor ligand binding domain complexed with a 19-norvitamin D compound==
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<StructureSection load='4ynk' size='340' side='right' caption='[[4ynk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4ynk' size='340' side='right'caption='[[4ynk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ynk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YNK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ynk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YNK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YW2:(1R,3R,7E,17BETA)-17-{(5S)-5-HYDROXY-5-[(3R,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YL]PENTA-1,3-DIYN-1-YL}-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YW2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ynk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynk OCA], [http://pdbe.org/4ynk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ynk RCSB], [http://www.ebi.ac.uk/pdbsum/4ynk PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YW2:(1R,3R,7E,17BETA)-17-{(5S)-5-HYDROXY-5-[(3R,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YL]PENTA-1,3-DIYN-1-YL}-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YW2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ynk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynk OCA], [https://pdbe.org/4ynk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ynk RCSB], [https://www.ebi.ac.uk/pdbsum/4ynk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ynk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ynk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ynk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ikura, T]]
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[[Category: Homo sapiens]]
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[[Category: Ito, N]]
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[[Category: Large Structures]]
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[[Category: Watarai, Y]]
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[[Category: Rattus norvegicus]]
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[[Category: Hormone receptor]]
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[[Category: Ikura T]]
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[[Category: Transcription]]
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[[Category: Ito N]]
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[[Category: Watarai Y]]

Current revision

Crystal structure of vitamin D receptor ligand binding domain complexed with a 19-norvitamin D compound

PDB ID 4ynk

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