This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5d3t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:46, 9 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==First bromodomain of BRD4 bound to inhibitor XD47==
==First bromodomain of BRD4 bound to inhibitor XD47==
-
<StructureSection load='5d3t' size='340' side='right' caption='[[5d3t]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
+
<StructureSection load='5d3t' size='340' side='right'caption='[[5d3t]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5d3t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D3T FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5d3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D3T FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56Y:4-ACETYL-N-(3-CARBAMOYLBENZYL)-3-ETHYL-N,5-DIMETHYL-1H-PYRROLE-2-CARBOXAMIDE'>56Y</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d3t OCA], [http://pdbe.org/5d3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d3t RCSB], [http://www.ebi.ac.uk/pdbsum/5d3t PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=56Y:4-ACETYL-N-(3-CARBAMOYLBENZYL)-3-ETHYL-N,5-DIMETHYL-1H-PYRROLE-2-CARBOXAMIDE'>56Y</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d3t OCA], [https://pdbe.org/5d3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d3t RCSB], [https://www.ebi.ac.uk/pdbsum/5d3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d3t ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 21:
</div>
</div>
<div class="pdbe-citations 5d3t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5d3t" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Huegle, M]]
+
[[Category: Homo sapiens]]
-
[[Category: Wohlwend, D]]
+
[[Category: Large Structures]]
-
[[Category: Bromodomain]]
+
[[Category: Huegle M]]
-
[[Category: Gene regulation]]
+
[[Category: Wohlwend D]]
-
[[Category: Inhibitor]]
+
-
[[Category: Transcription]]
+

Current revision

First bromodomain of BRD4 bound to inhibitor XD47

PDB ID 5d3t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5d3t"
Personal tools