4d7f

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==Human FXIa in complex with small molecule inhibitors.==
==Human FXIa in complex with small molecule inhibitors.==
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<StructureSection load='4d7f' size='340' side='right' caption='[[4d7f]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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<StructureSection load='4d7f' size='340' side='right'caption='[[4d7f]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d7f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D7F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D7F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IXA:N-[(2S)-1-({4-[(DIAMINOMETHYLIDENE)AMINO]BUTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>IXA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d76|4d76]], [[4d7g|4d7g]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IXA:N-[(2S)-1-({4-[(DIAMINOMETHYLIDENE)AMINO]BUTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>IXA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7f OCA], [https://pdbe.org/4d7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d7f RCSB], [https://www.ebi.ac.uk/pdbsum/4d7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7f OCA], [http://pdbe.org/4d7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d7f RCSB], [http://www.ebi.ac.uk/pdbsum/4d7f PDBsum]</span></td></tr>
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</table>
</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
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==See Also==
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== Function ==
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*[[Factor XIa 3D structures|Factor XIa 3D structures]]
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[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Coagulation factor XIa]]
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[[Category: Homo sapiens]]
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[[Category: Akerud, T]]
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[[Category: Large Structures]]
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[[Category: Borjesson, U]]
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[[Category: Akerud T]]
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[[Category: Jacso, T]]
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[[Category: Borjesson U]]
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[[Category: Norberg, M]]
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[[Category: Jacso T]]
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[[Category: Olsson, T]]
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[[Category: Norberg M]]
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[[Category: Oster, L]]
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[[Category: Olsson T]]
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[[Category: Redzick, A]]
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[[Category: Oster L]]
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[[Category: Sandmark, J]]
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[[Category: Redzick A]]
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[[Category: Ullah, V]]
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[[Category: Sandmark J]]
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[[Category: Hydrolase]]
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[[Category: Ullah V]]
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[[Category: Serine protease]]
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Current revision

Human FXIa in complex with small molecule inhibitors.

PDB ID 4d7f

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OCA

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