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4uez

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==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH==
==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH==
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<StructureSection load='4uez' size='340' side='right' caption='[[4uez]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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<StructureSection load='4uez' size='340' side='right'caption='[[4uez]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uez]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UEZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UEZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFF:(2S)-3-[(R)-{(1R)-1-[(N-ACETYL-L-LEUCYL)AMINO]-2-PHENYLETHYL}(HYDROXY)PHOSPHORYL]-2-BENZYLPROPANOIC+ACID'>LFF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uee|4uee]], [[4uef|4uef]], [[4uf4|4uf4]], [[5aek|5aek]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFF:(2S)-3-[(R)-{(1R)-1-[(N-ACETYL-L-LEUCYL)AMINO]-2-PHENYLETHYL}(HYDROXY)PHOSPHORYL]-2-BENZYLPROPANOIC+ACID'>LFF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uez OCA], [https://pdbe.org/4uez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uez RCSB], [https://www.ebi.ac.uk/pdbsum/4uez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uez ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uez OCA], [http://pdbe.org/4uez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uez RCSB], [http://www.ebi.ac.uk/pdbsum/4uez PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
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[https://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
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==See Also==
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carboxypeptidase A]]
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[[Category: Homo sapiens]]
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[[Category: Aviles, F X]]
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[[Category: Large Structures]]
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[[Category: Costenaro, L]]
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[[Category: Aviles FX]]
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[[Category: Covaleda, G]]
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[[Category: Costenaro L]]
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[[Category: Devel, L]]
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[[Category: Covaleda G]]
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[[Category: Dive, V]]
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[[Category: Devel L]]
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[[Category: Gallego, P]]
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[[Category: Dive V]]
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[[Category: Reverter, D]]
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[[Category: Gallego P]]
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[[Category: Carboxypeptidase]]
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[[Category: Reverter D]]
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[[Category: Cpa1]]
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[[Category: Hydrolase]]
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[[Category: Phosphinic inhibitor]]
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Current revision

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH

PDB ID 4uez

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OCA

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