5hda

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==Crystal Structure of the BS69 coiled coil-MYND domains bound to an EBNA2 PXLXP motif==
==Crystal Structure of the BS69 coiled coil-MYND domains bound to an EBNA2 PXLXP motif==
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<StructureSection load='5hda' size='340' side='right' caption='[[5hda]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='5hda' size='340' side='right'caption='[[5hda]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hda]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HDA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HDA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3899&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hda OCA], [http://pdbe.org/5hda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hda RCSB], [http://www.ebi.ac.uk/pdbsum/5hda PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hda OCA], [https://pdbe.org/5hda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hda RCSB], [https://www.ebi.ac.uk/pdbsum/5hda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hda ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZMY11_HUMAN ZMY11_HUMAN]] Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.<ref>PMID:16565076</ref> <ref>PMID:10734313</ref> [[http://www.uniprot.org/uniprot/EBNA2_EBVB9 EBNA2_EBVB9]] Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells.<ref>PMID:19126642</ref>
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[https://www.uniprot.org/uniprot/ZMY11_HUMAN ZMY11_HUMAN] Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.<ref>PMID:16565076</ref> <ref>PMID:10734313</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Harter, M]]
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[[Category: Homo sapiens]]
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[[Category: Song, J]]
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[[Category: Human herpesvirus 4 strain B95-8]]
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[[Category: Bs69]]
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[[Category: Large Structures]]
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[[Category: Coiled-coil]]
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[[Category: Harter M]]
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[[Category: Ebna2]]
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[[Category: Song J]]
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[[Category: Immune system]]
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[[Category: Mynd]]
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[[Category: Zmynd11]]
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Current revision

Crystal Structure of the BS69 coiled coil-MYND domains bound to an EBNA2 PXLXP motif

PDB ID 5hda

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