1bvj

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[[Image:1bvj.gif|left|200px]]
 
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{{Structure
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==HIV-1 RNA A-RICH HAIRPIN LOOP==
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|PDB= 1bvj |SIZE=350|CAPTION= <scene name='initialview01'>1bvj</scene>
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<StructureSection load='1bvj' size='340' side='right'caption='[[1bvj]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1bvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(MAL_ISOLATE) Human immunodeficiency virus type 1 (MAL ISOLATE)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BVJ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bvj OCA], [https://pdbe.org/1bvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bvj RCSB], [https://www.ebi.ac.uk/pdbsum/1bvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bvj ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bvj OCA], [http://www.ebi.ac.uk/pdbsum/1bvj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bvj RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''HIV-1 RNA A-RICH HAIRPIN LOOP'''
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==Overview==
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Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
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==About this Structure==
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HIV-1 A-rich RNA loop mimics the tRNA anticodon structure.,Puglisi EV, Puglisi JD Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:9846871<ref>PMID:9846871</ref>
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1BVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA].
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==Reference==
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HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9846871 9846871]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Puglisi, E V.]]
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[[Category: Puglisi, J D.]]
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[[Category: hiv-1 genomic rna]]
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[[Category: reverse transcriptase initiation]]
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[[Category: rna hairpin loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:09:08 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1bvj" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Puglisi EV]]
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[[Category: Puglisi JD]]

Current revision

HIV-1 RNA A-RICH HAIRPIN LOOP

PDB ID 1bvj

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