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1w8g

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[[Image:1w8g.gif|left|200px]]<br />
 
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<applet load="1w8g" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1w8g, resolution 2.00&Aring;" />
 
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'''CRYSTAL STRUCTURE OF E. COLI K-12 YGGS'''<br />
 
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==About this Structure==
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==CRYSTAL STRUCTURE OF E. COLI K-12 YGGS==
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1W8G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PLP and ICT as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8G OCA].
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<StructureSection load='1w8g' size='340' side='right'caption='[[1w8g]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Escherichia coli]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1w8g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W8G FirstGlance]. <br>
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[[Category: Bignon, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Cambillau, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ICT:ISOCITRIC+ACID'>ICT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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[[Category: Gruez, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8g OCA], [https://pdbe.org/1w8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w8g RCSB], [https://www.ebi.ac.uk/pdbsum/1w8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w8g ProSAT]</span></td></tr>
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[[Category: Pagot, F.]]
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</table>
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[[Category: Roig-Zamboni, V.]]
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== Function ==
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[[Category: Spinelli, S.]]
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[https://www.uniprot.org/uniprot/PLPHP_ECOLI PLPHP_ECOLI] Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins (PubMed:26872910). Does not have amino acid racemase activity (PubMed:24097949).<ref>PMID:24097949</ref> <ref>PMID:26872910</ref>
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[[Category: Sulzenbacher, G.]]
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== Evolutionary Conservation ==
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[[Category: Vincentelli, R.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: ICT]]
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Check<jmol>
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[[Category: PLP]]
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<jmolCheckbox>
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[[Category: hypothetical protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/1w8g_consurf.spt"</scriptWhenChecked>
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[[Category: plp-binding protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: putative enzyme with plp-binding domain]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: structural genomics]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w8g ConSurf].
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:07:49 2007''
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Bignon C]]
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[[Category: Cambillau C]]
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[[Category: Gruez A]]
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[[Category: Pagot F]]
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[[Category: Roig-Zamboni V]]
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[[Category: Spinelli S]]
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[[Category: Sulzenbacher G]]
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[[Category: Vincentelli R]]

Current revision

CRYSTAL STRUCTURE OF E. COLI K-12 YGGS

PDB ID 1w8g

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