5hmh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5hmh is ON HOLD Authors: Scapin, G. Description: HDM2 in complex with a 3,3-Disubstituted Piperidine Category: Unreleased Structures [[Category...)
Current revision (12:32, 6 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5hmh is ON HOLD
+
==HDM2 in complex with a 3,3-Disubstituted Piperidine==
 +
<StructureSection load='5hmh' size='340' side='right'caption='[[5hmh]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5hmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HMH FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=62R:4-[2-(4-{[(2R,3S)-2-PROPYL-1-{[4-(TRIFLUOROMETHYL)PYRIDIN-3-YL]CARBONYL}-3-{[5-(TRIFLUOROMETHYL)THIOPHEN-3-YL]OXY}PIPERIDIN-3-YL]CARBONYL}PIPERAZIN-1-YL)PHENOXY]BUTANOIC+ACID'>62R</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmh OCA], [https://pdbe.org/5hmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hmh RCSB], [https://www.ebi.ac.uk/pdbsum/5hmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hmh ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
-
Authors: Scapin, G.
+
==See Also==
-
 
+
*[[MDM2 3D structures|MDM2 3D structures]]
-
Description: HDM2 in complex with a 3,3-Disubstituted Piperidine
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Scapin, G]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Scapin G]]

Current revision

HDM2 in complex with a 3,3-Disubstituted Piperidine

PDB ID 5hmh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5hmh"
Personal tools