This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5hnt
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5hnt is ON HOLD Authors: Cuiyun Li, Yingning Zhao, Hong Zhang, Xiaopeng Hu Description: Crystal Structure of AKR1C3 complexed with CAPE [[Category:...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of AKR1C3 complexed with CAPE== | |
| - | + | <StructureSection load='5hnt' size='340' side='right'caption='[[5hnt]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hnt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HNT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=QAP:2-PHENYLETHYL+(2E)-3-(3,4-DIHYDROXYPHENYL)PROP-2-ENOATE'>QAP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnt OCA], [https://pdbe.org/5hnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hnt RCSB], [https://www.ebi.ac.uk/pdbsum/5hnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnt ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hu X]] | ||
| + | [[Category: Li C]] | ||
| + | [[Category: Zhang H]] | ||
| + | [[Category: Zhao Y]] | ||
Current revision
Crystal Structure of AKR1C3 complexed with CAPE
| |||||||||||
Categories: Homo sapiens | Large Structures | Hu X | Li C | Zhang H | Zhao Y
