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5e7n
From Proteopedia
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==Crystal Structure of RPA70N in complex with VU0085636== | ==Crystal Structure of RPA70N in complex with VU0085636== | ||
| - | <StructureSection load='5e7n' size='340' side='right' caption='[[5e7n]], [[Resolution|resolution]] 1.21Å' scene=''> | + | <StructureSection load='5e7n' size='340' side='right'caption='[[5e7n]], [[Resolution|resolution]] 1.21Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5e7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7N OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5e7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E7N FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5KR:2-({3-[(4-BROMOPHENYL)SULFAMOYL]-4-METHYLBENZOYL}AMINO)BENZOIC+ACID'>5KR</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5KR:2-({3-[(4-BROMOPHENYL)SULFAMOYL]-4-METHYLBENZOYL}AMINO)BENZOIC+ACID'>5KR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e7n OCA], [https://pdbe.org/5e7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e7n RCSB], [https://www.ebi.ac.uk/pdbsum/5e7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e7n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5e7n" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5e7n" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Bates | + | [[Category: Homo sapiens]] |
| - | [[Category: Browning | + | [[Category: Large Structures]] |
| - | [[Category: Camper | + | [[Category: Bates BS]] |
| - | [[Category: Chazin | + | [[Category: Browning CF]] |
| - | [[Category: Feldkamp | + | [[Category: Camper D]] |
| - | [[Category: Fesik | + | [[Category: Chazin WJ]] |
| - | [[Category: Gilston | + | [[Category: Feldkamp MD]] |
| - | [[Category: Kuznetsov | + | [[Category: Fesik SW]] |
| - | [[Category: Olejniczak | + | [[Category: Gilston BA]] |
| - | [[Category: Patrone | + | [[Category: Kuznetsov A]] |
| - | [[Category: Pelz | + | [[Category: Olejniczak ET]] |
| - | [[Category: Rossanese | + | [[Category: Patrone JD]] |
| - | [[Category: Souza-Fagundes | + | [[Category: Pelz NF]] |
| - | [[Category: Vangamudi | + | [[Category: Rossanese OW]] |
| - | [[Category: Waterson | + | [[Category: Souza-Fagundes EM]] |
| - | + | [[Category: Vangamudi B]] | |
| - | + | [[Category: Waterson AG]] | |
| - | + | ||
Current revision
Crystal Structure of RPA70N in complex with VU0085636
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Categories: Homo sapiens | Large Structures | Bates BS | Browning CF | Camper D | Chazin WJ | Feldkamp MD | Fesik SW | Gilston BA | Kuznetsov A | Olejniczak ET | Patrone JD | Pelz NF | Rossanese OW | Souza-Fagundes EM | Vangamudi B | Waterson AG
