2nb5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2nb5 is ON HOLD Authors: Armstrong, D.A., Franke, B., Elliott, A.G., Mylne, J.S., Rosengren, K. Description: NMR solution structure of PawS Derived...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of PawS Derived Peptide 9 (PDP-9)== | |
| + | <StructureSection load='2nb5' size='340' side='right'caption='[[2nb5]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2nb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Perymenium_macrocephalum Perymenium macrocephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NB5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nb5 OCA], [https://pdbe.org/2nb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2nb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nb5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A023GYK7_PERMO A0A023GYK7_PERMO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We recently isolated and described the evolutionary origin of a diverse class of small single-disulfide bonded peptides derived from Preproalbumin with SFTI-1 (PawS1) proteins in the seeds of flowering plants (Asteraceae). The founding member of the PawS derived peptide (PDP) family is the potent trypsin inhibitor SFTI-1 (sunflower trypsin inhibitor-1) from Helianthus annuus, the common sunflower. Here we provide additional structures and describe the structural diversity of this new class of small peptides, derived from solution NMR studies, in detail. We show that although most have a similar backbone framework with a single disulfide bond and in many cases a head-to-tail cyclized backbone, they all have their own characteristics in terms of projections of side-chains, flexibility and physiochemical properties, attributed to the variety of their sequences. Small cyclic and constrained peptides are popular as drug scaffolds in the pharmaceutical industry and our data highlight how amino acid side-chains can fine-tune conformations in these promising peptides. | ||
| - | + | Natural structural diversity within a conserved cyclic peptide scaffold.,Elliott AG, Franke B, Armstrong DA, Craik DJ, Mylne JS, Rosengren KJ Amino Acids. 2016 Oct 1. PMID:27695949<ref>PMID:27695949</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2nb5" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Perymenium macrocephalum]] | ||
| + | [[Category: Armstrong DA]] | ||
| + | [[Category: Elliott AG]] | ||
| + | [[Category: Franke B]] | ||
| + | [[Category: Mylne JS]] | ||
| + | [[Category: Rosengren KJ]] | ||
Current revision
NMR solution structure of PawS Derived Peptide 9 (PDP-9)
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