5hrj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5hrj is ON HOLD Authors: Hongfang Ma, Longguang Jiang, Songlin Qiao, Gaiping Zhang, Rui Li Description: Crystal structure of the scavenger receptor...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163== | |
| - | + | <StructureSection load='5hrj' size='340' side='right'caption='[[5hrj]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HRJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [https://pdbe.org/5hrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [https://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C163A_PIG C163A_PIG] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref> After shedding, the soluble form (sCD163) may play an anti-inflammatory role. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Jiang L]] | ||
| + | [[Category: Li R]] | ||
| + | [[Category: Ma H]] | ||
| + | [[Category: Qiao S]] | ||
| + | [[Category: Zhang G]] | ||
Current revision
Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163
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Categories: Large Structures | Sus scrofa | Jiang L | Li R | Ma H | Qiao S | Zhang G
