1c9i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:41, 7 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1c9i.jpg|left|200px]]
 
-
{{Structure
+
==PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN==
-
|PDB= 1c9i |SIZE=350|CAPTION= <scene name='initialview01'>1c9i</scene>, resolution 2.90&Aring;
+
<StructureSection load='1c9i' size='340' side='right'caption='[[1c9i]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1c9i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C9I FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9i OCA], [https://pdbe.org/1c9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c9i RCSB], [https://www.ebi.ac.uk/pdbsum/1c9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c9i ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=[[1c9l|1C9L]]
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9i OCA], [http://www.ebi.ac.uk/pdbsum/1c9i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c9i RCSB]</span>
+
[https://www.uniprot.org/uniprot/CLH1_RAT CLH1_RAT] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/1c9i_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c9i ConSurf].
 +
<div style="clear:both"></div>
-
'''PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN'''
+
==See Also==
-
 
+
*[[Clathrin 3D structures|Clathrin 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The "WD40" domain is a widespread recognition module for linking partner proteins in intracellular networks of signaling and sorting. The clathrin amino-terminal domain, which directs incorporation of cargo into coated pits, is a beta-propeller closely related in structure to WD40 modules. The crystallographically determined structures of complexes of the clathrin-terminal domain with peptides derived from two different cargo adaptors, beta-arrestin 2 and the beta-subunit of the AP-3 complex, reveal strikingly similar peptide-in-groove interactions. The two peptides in our structures contain related, five-residue motifs, which form the core of their contact with clathrin. A number of other proteins involved in endocytosis have similar "clathrin-box" motifs, and it therefore is likely that they all bind the terminal domain in the same way. We propose that a peptide-in-groove interaction is an important general mode by which beta-propellers recognize specific target proteins.
+
[[Category: Homo sapiens]]
-
 
+
[[Category: Large Structures]]
-
==About this Structure==
+
-
1C9I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9I OCA].
+
-
 
+
-
==Reference==
+
-
Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin., ter Haar E, Harrison SC, Kirchhausen T, Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1096-100. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10655490 10655490]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Single protein]]
+
[[Category: Harrison SC]]
-
[[Category: Haar, E ter.]]
+
[[Category: Kirchhausen T]]
-
[[Category: Harrison, S. C.]]
+
[[Category: Ter Haar E]]
-
[[Category: Kirchhausen, T.]]
+
-
[[Category: beta-propeller]]
+
-
[[Category: helical hairpin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:24 2008''
+

Current revision

PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN

PDB ID 1c9i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c9i"
Personal tools