5htc

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'''Unreleased structure'''
 
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The entry 5htc is ON HOLD
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==Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3372==
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<StructureSection load='5htc' size='340' side='right'caption='[[5htc]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5htc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HTC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66M:(2R)-2-{[6-({[(2S,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]CARBONYL}AMINO)HEXANOYL]AMINO}BUTANEDIOIC+ACID+(NON-PREFERRED+NAME)'>66M</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5htc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5htc OCA], [https://pdbe.org/5htc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5htc RCSB], [https://www.ebi.ac.uk/pdbsum/5htc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5htc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
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Authors: Chaikuad, A., Heroven, C., Lavogina, D., Kestav, K., Uri, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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Description: Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3372
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Chaikuad, A]]
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__TOC__
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[[Category: Lavogina, D]]
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</StructureSection>
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[[Category: Knapp, S]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Synthetic construct]]
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[[Category: Von Delft, F]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A.M]]
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[[Category: Bountra C]]
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[[Category: Heroven, C]]
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[[Category: Chaikuad A]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Edwards AM]]
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[[Category: Uri, A]]
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[[Category: Heroven C]]
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[[Category: Kestav, K]]
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[[Category: Kestav K]]
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[[Category: Knapp S]]
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[[Category: Lavogina D]]
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[[Category: Uri A]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3372

PDB ID 5htc

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