5huq

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m (Protected "5huq" [edit=sysop:move=sysop])
Current revision (07:23, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5huq is ON HOLD
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==A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase==
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<StructureSection load='5huq' size='340' side='right'caption='[[5huq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Desguin, B., Zhang, T., Soumillion, P., Hols, P., Hu, J., Hausinger, R.P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5huq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum Lactiplantibacillus plantarum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4yns 4yns]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HUQ FirstGlance]. <br>
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Description: A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4EY:1-[(2R,3R,4S,5R)-3,4-BIS(OXIDANYL)-5-(PHOSPHONOOXYMETHYL)OXOLAN-2-YL]-5-METHANETHIOYL-PYRIDINE-3-CARBOTHIOIC+S-ACID'>4EY</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Hols, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5huq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huq OCA], [https://pdbe.org/5huq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5huq RCSB], [https://www.ebi.ac.uk/pdbsum/5huq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5huq ProSAT]</span></td></tr>
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[[Category: Zhang, T]]
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</table>
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[[Category: Desguin, B]]
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== Function ==
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[[Category: Hausinger, R.P]]
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[https://www.uniprot.org/uniprot/LARA_LACPL LARA_LACPL] Catalyzes the interconversion between the D- and L-isomers of lactate (PubMed:24710389, PubMed:26138974). May act as a rescue enzyme to ensure D-lactate production in physiological conditions where its production by the D-lactate dehydrogenase LdhD is not sufficient (PubMed:16166538). D-Lactate is absolutely required for growth of L.plantarum and is an essential component of the cell wall peptidoglycan in this species, where it is incorporated as the last residue of the muramoyl-pentadepsipeptide peptidoglycan precursor; its incorporation confers high level of vancomycin resistance (PubMed:16166538).<ref>PMID:16166538</ref> <ref>PMID:24710389</ref> <ref>PMID:26138974</ref>
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[[Category: Hu, J]]
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== References ==
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[[Category: Soumillion, P]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Lactiplantibacillus plantarum]]
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[[Category: Large Structures]]
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[[Category: Desguin B]]
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[[Category: Hausinger RP]]
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[[Category: Hols P]]
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[[Category: Hu J]]
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[[Category: Soumillion P]]
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[[Category: Zhang T]]

Current revision

A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase

PDB ID 5huq

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