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| - | ==The crystal structure of mouse TLR4/MD-2/lipid A complex==
| + | #REDIRECT [[5ijd]] This PDB entry is obsolete and replaced by 5ijd |
| - | <StructureSection load='5hg6' size='340' side='right' caption='[[5hg6]], [[Resolution|resolution]] 2.70Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5hg6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HG6 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=LP4:2-DEOXY-3-O-[(3R)-3-HYDROXYTETRADECANOYL]-2-{[(3R)-3-HYDROXYTETRADECANOYL]AMINO}-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>LP4</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hg3|5hg3]], [[5hg4|5hg4]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hg6 OCA], [http://pdbe.org/5hg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hg6 RCSB], [http://www.ebi.ac.uk/pdbsum/5hg6 PDBsum]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE]] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE]] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref> [[http://www.uniprot.org/uniprot/LY96_MOUSE LY96_MOUSE]] Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity).
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Berger, M]]
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| - | [[Category: Beutler, B]]
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| - | [[Category: Boger, D L]]
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| - | [[Category: Choi, J H]]
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| - | [[Category: Huang, H]]
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| - | [[Category: Jones, B T]]
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| - | [[Category: Moresco, E M]]
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| - | [[Category: Morin, M D]]
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| - | [[Category: Shi, H]]
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| - | [[Category: Su, L]]
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| - | [[Category: Surakattula, M]]
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| - | [[Category: Wang, K]]
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| - | [[Category: Wang, Y]]
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| - | [[Category: Whitby, L R]]
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| - | [[Category: Zhan, X]]
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| - | [[Category: Zhang, H]]
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| - | [[Category: Immune response]]
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| - | [[Category: Immune system]]
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| - | [[Category: Natural agonist]]
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| - | [[Category: Protein complex]]
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