3i4r

<StructureSection load='3i4r' size='340' side='right' caption='[[3i4r]], [[Resolution|resolution]] 3.53&Aring;' scene=''>

<table><tr><td colspan='2'>[[3i4r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I4R FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4r OCA], [http://pdbe.org/3i4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i4r RCSB], [http://www.ebi.ac.uk/pdbsum/3i4r PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/NU107_HUMAN NU107_HUMAN]] Essential component of nuclear pore complex. Required for the assembly of peripheral proteins into the nuclear pore complex.<ref>PMID:12552102</ref> [[http://www.uniprot.org/uniprot/NU133_HUMAN NU133_HUMAN]] Involved in poly(A)+ RNA transport.<ref>PMID:11684705</ref>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/3i4r_consurf.spt"</scriptWhenChecked>

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== Publication Abstract from PubMed ==

The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the eukaryotic cell and forms the exclusive gateway to the nucleus. The stable, approximately 15-20-MDa scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-fold axis. Here we present crystal structures of two large architectural units, yNup170(979-1502) and hNup107(658-925) x hNup133(517-1156), each a constituent of one of the two multiprotein complexes. Conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor. Together with the previously established ancestral coatomer element (ACE1), these two elements constitute the major alpha-helical building blocks of the NPC scaffold and define its branched, lattice-like architecture, similar to vesicle coats like COPII. We hypothesize that the extant NPC evolved early during eukaryotic evolution from a rudimentary structure composed of several identical copies of a few ancestral elements, later diversified and specified by gene duplication.

Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.,Whittle JR, Schwartz TU J Biol Chem. 2009 Oct 9;284(41):28442-52. Epub 2009 Aug 11. PMID:19674973<ref>PMID:19674973</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3i4r" style="background-color:#fffaf0;"></div>

*[[Nucleoporin|Nucleoporin]]

[[Category: Human]]

[[Category: Schwartz, T U]]

[[Category: Whittle, J R.R]]

[[Category: Kinetochore]]

[[Category: Transport]]