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2jq8

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==Solution structure of the Somatomedin B domain from vitronectin produced in Pichia pastoris==
==Solution structure of the Somatomedin B domain from vitronectin produced in Pichia pastoris==
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<StructureSection load='2jq8' size='340' side='right' caption='[[2jq8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2jq8' size='340' side='right'caption='[[2jq8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jq8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQ8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ssu|1ssu]], [[1s4g|1s4g]], [[1oc0|1oc0]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VTN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jq8 OCA], [https://pdbe.org/2jq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jq8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jq8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jq8 OCA], [http://pdbe.org/2jq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jq8 RCSB], [http://www.ebi.ac.uk/pdbsum/2jq8 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VTNC_HUMAN VTNC_HUMAN]] Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
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[https://www.uniprot.org/uniprot/VTNC_HUMAN VTNC_HUMAN] Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jq8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jq8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gaardsvoll, H]]
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[[Category: Large Structures]]
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[[Category: Hirschberg, D]]
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[[Category: Gaardsvoll H]]
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[[Category: Jansson, A]]
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[[Category: Hirschberg D]]
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[[Category: Jorgensen, T J.D]]
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[[Category: Jansson A]]
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[[Category: Mayasundari, A]]
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[[Category: Jorgensen TJD]]
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[[Category: Nielbo, S]]
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[[Category: Mayasundari A]]
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[[Category: Peterson, C B]]
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[[Category: Nielbo S]]
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[[Category: Poulsen, F M]]
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[[Category: Peterson CB]]
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[[Category: Cell adhesion]]
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[[Category: Poulsen FM]]
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[[Category: Disulfide-rich domain]]
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[[Category: Pai-1]]
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[[Category: Somatomedin b domain]]
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[[Category: Upar]]
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[[Category: Vitronectin]]
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Current revision

Solution structure of the Somatomedin B domain from vitronectin produced in Pichia pastoris

PDB ID 2jq8

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