2v5e
From Proteopedia
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==The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.== | ==The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.== | ||
| - | <StructureSection load='2v5e' size='340' side='right' caption='[[2v5e]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='2v5e' size='340' side='right'caption='[[2v5e]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2v5e]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2v5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5E FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GU4:2,3,4,6-TETRA-O-SULFONATO-ALPHA-D-GLUCOPYRANOSE'>GU4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900013:sucrose+octasulfate'>PRD_900013</scene>, <scene name='pdbligand=YYJ:1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose'>YYJ</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5e OCA], [https://pdbe.org/2v5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5e RCSB], [https://www.ebi.ac.uk/pdbsum/2v5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5e ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/GDNF_HUMAN GDNF_HUMAN]] Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3) [MIM:[http://omim.org/entry/613711 613711]]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.<ref>PMID:8968758</ref> <ref>PMID:8896568</ref> <ref>PMID:8896569</ref> <ref>PMID:10917288</ref> Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:[http://omim.org/entry/209880 209880]]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.<ref>PMID:9497256</ref> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GFRA1_RAT GFRA1_RAT] Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5e_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5e_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bespalov | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Goldman | + | [[Category: Bespalov MM]] |
| - | [[Category: Jurvansuu | + | [[Category: Goldman A]] |
| - | [[Category: Leppanen | + | [[Category: Jurvansuu J-M]] |
| - | [[Category: Parkash | + | [[Category: Leppanen V-M]] |
| - | [[Category: Runeberg-Roos | + | [[Category: Parkash V]] |
| - | [[Category: Saarma | + | [[Category: Runeberg-Roos P]] |
| - | [[Category: Sidorova | + | [[Category: Saarma M]] |
| - | [[Category: Virtanen | + | [[Category: Sidorova YA]] |
| - | + | [[Category: Virtanen H]] | |
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Current revision
The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.
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