2gv8

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==Crystal structure of flavin-containing monooxygenase (FMO) from S.pombe and NADPH cofactor complex==
==Crystal structure of flavin-containing monooxygenase (FMO) from S.pombe and NADPH cofactor complex==
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<StructureSection load='2gv8' size='340' side='right' caption='[[2gv8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2gv8' size='340' side='right'caption='[[2gv8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GV8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GV8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vqw|1vqw]], [[2gvc|2gvc]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gv8 OCA], [https://pdbe.org/2gv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gv8 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2gv8 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gv8 OCA], [http://pdbe.org/2gv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gv8 RCSB], [http://www.ebi.ac.uk/pdbsum/2gv8 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2gv8 TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FMO1_SCHPO FMO1_SCHPO]] Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins (By similarity).
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[https://www.uniprot.org/uniprot/FMO1_SCHPO FMO1_SCHPO] Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/2gv8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/2gv8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Monooxygenase|Monooxygenase]]
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 356]]
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[[Category: Large Structures]]
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[[Category: Burley, S K]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Eswaramoorthy, S]]
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[[Category: Burley SK]]
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[[Category: Structural genomic]]
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[[Category: Eswaramoorthy S]]
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[[Category: Swaminathan, S]]
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[[Category: Swaminathan S]]
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[[Category: Cofactor complex]]
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[[Category: Fad]]
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[[Category: Fmo]]
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[[Category: Nadph]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Oxidoreductase]]
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[[Category: Oxygenase]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal structure of flavin-containing monooxygenase (FMO) from S.pombe and NADPH cofactor complex

PDB ID 2gv8

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