This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1cks

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:43, 7 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1cks.jpg|left|200px]]
 
-
{{Structure
+
==HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL==
-
|PDB= 1cks |SIZE=350|CAPTION= <scene name='initialview01'>1cks</scene>, resolution 2.1&Aring;
+
<StructureSection load='1cks' size='340' side='right'caption='[[1cks]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
<table><tr><td colspan='2'>[[1cks]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKS FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cks OCA], [https://pdbe.org/1cks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cks RCSB], [https://www.ebi.ac.uk/pdbsum/1cks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cks ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cks OCA], [http://www.ebi.ac.uk/pdbsum/1cks PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cks RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/CKS2_HUMAN CKS2_HUMAN] Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1cks_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cks ConSurf].
 +
<div style="clear:both"></div>
-
'''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''
+
==See Also==
-
 
+
*[[Cyclin-dependent kinase regulatory subunit 3D structures|Cyclin-dependent kinase regulatory subunit 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The cell cycle regulatory protein CksHs2 binds to the catalytic subunit of the cyclin-dependent kinases (Cdk's) and is essential for their biological function. The crystal structure of the protein was determined at 2.1 A resolution. The CksHs2 structure is an unexpected hexamer formed by the symmetric assembly of three interlocked dimers into an unusual 12-stranded beta barrel fold that may represent a prototype for this class of protein structures. Sequence-conserved regions form the unusual beta strand exchange between the subunits of the dimer, and the metal and anion binding sites associated with the hexamer assembly. The two other sequence-conserved regions line a 12 A diameter tunnel through the beta barrel and form the six exposed, charged helix pairs. Six kinase subunits can be modeled to bind the assembled hexamer without collision, and therefore this CksHs2 hexamer may participate in cell cycle control by acting as the hub for Cdk multimerization in vivo.
+
-
 
+
-
==About this Structure==
+
-
1CKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA].
+
-
 
+
-
==Reference==
+
-
Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8211159 8211159]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arvai, A S.]]
+
[[Category: Arvai AS]]
-
[[Category: Parge, H E.]]
+
[[Category: Parge HE]]
-
[[Category: Tainer, J A.]]
+
[[Category: Tainer JA]]
-
[[Category: cell division]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:23:43 2008''
+

Current revision

HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL

PDB ID 1cks

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cks"
Personal tools