2jle

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:38, 9 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==NOVEL INDAZOLE NNRTIS CREATED USING MOLECULAR TEMPLATE HYBRIDIZATION BASED ON CRYSTALLOGRAPHIC OVERLAYS==
+
 
-
<StructureSection load='2jle' size='340' side='right' caption='[[2jle]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+
==Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays==
 +
<StructureSection load='2jle' size='340' side='right'caption='[[2jle]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2jle]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JLE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2jle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JLE FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I15:5-[(5-FLUORO-3-METHYL-1H-INDAZOL-4-YL)OXY]BENZENE-1,3-DICARBONITRILE'>I15</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jle OCA], [http://pdbe.org/2jle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jle RCSB], [http://www.ebi.ac.uk/pdbsum/2jle PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I15:5-[(5-FLUORO-3-METHYL-1H-INDAZOL-4-YL)OXY]BENZENE-1,3-DICARBONITRILE'>I15</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jle OCA], [https://pdbe.org/2jle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jle RCSB], [https://www.ebi.ac.uk/pdbsum/2jle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jle ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q72547_9HIV1 Q72547_9HIV1]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jle_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jle_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 27: Line 31:
==See Also==
==See Also==
-
*[[Reverse transcriptase|Reverse transcriptase]]
+
*[[Reverse transcriptase 3D structures|Reverse transcriptase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Allan, G]]
+
[[Category: Human immunodeficiency virus 1]]
-
[[Category: Barba, O]]
+
[[Category: Large Structures]]
-
[[Category: Burt, C]]
+
[[Category: Allan G]]
-
[[Category: Corbau, R]]
+
[[Category: Barba O]]
-
[[Category: Dupont, T]]
+
[[Category: Burt C]]
-
[[Category: Irving, S]]
+
[[Category: Corbau R]]
-
[[Category: Jones, L H]]
+
[[Category: Dupont T]]
-
[[Category: Mowbray, C E]]
+
[[Category: Irving S]]
-
[[Category: Phillips, C]]
+
[[Category: Jones LH]]
-
[[Category: Swain, N A]]
+
[[Category: Mowbray CE]]
-
[[Category: Webster, R]]
+
[[Category: Phillips C]]
-
[[Category: Westby, M]]
+
[[Category: Swain NA]]
-
[[Category: Aid]]
+
[[Category: Webster R]]
-
[[Category: Aspartyl protease]]
+
[[Category: Westby M]]
-
[[Category: Capsid maturation]]
+
-
[[Category: Capsid protein]]
+
-
[[Category: Dna integration]]
+
-
[[Category: Dna recombination]]
+
-
[[Category: Dna-directed dna polymerase]]
+
-
[[Category: Endonuclease]]
+
-
[[Category: Hiv-1]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Multifunctional enzyme]]
+
-
[[Category: Myristate]]
+
-
[[Category: Nnrti]]
+
-
[[Category: Nuclease]]
+
-
[[Category: Nucleotidyltransferase]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Protease]]
+
-
[[Category: Rna-binding]]
+
-
[[Category: Rna-directed dna polymerase]]
+
-
[[Category: Transferase]]
+
-
[[Category: Viral nucleoprotein]]
+
-
[[Category: Virion]]
+
-
[[Category: Zinc-finger]]
+

Current revision

Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays

PDB ID 2jle

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jle"
Personal tools