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1cmb

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THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cmb"

Categories: Escherichia coli | Large Structures | Phillips K | Phillips SEV | Rafferty JB

@@ Line 1: / Line 1: @@
-[[Image:1cmb.gif|left|200px]]
- {{Structure
+==THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR==
-|PDB= 1cmb |SIZE=350|CAPTION= <scene name='initialview01'>1cmb</scene>, resolution 1.8&Aring;
+<StructureSection load='1cmb' size='340' side='right'caption='[[1cmb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+<table><tr><td colspan='2'>[[1cmb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CMB FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cmb OCA], [https://pdbe.org/1cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cmb RCSB], [https://www.ebi.ac.uk/pdbsum/1cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cmb ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cmb OCA], [http://www.ebi.ac.uk/pdbsum/1cmb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cmb RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/METJ_ECOLI METJ_ECOLI] This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated.[HAMAP-Rule:MF_00744]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/1cmb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cmb ConSurf].
+<div style="clear:both"></div>
-'''THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''
+==See Also==
+*[[Met repressor|Met repressor]]
+__TOC__
-==Overview==
+</StructureSection>
-The three-dimensional crystal structure of met repressor, in the presence or absence of bound corepressor (S-adenosylmethionine), shows a dimer of intertwined monomers, which do not have the helix-turn-helix motif characteristic of other bacterial repressor and activator structures. We propose that the interaction of met repressor with DNA occurs through either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.
-==About this Structure==
-CMB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMB OCA].
-==Reference==
-Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor., Rafferty JB, Somers WS, Saint-Girons I, Phillips SE, Nature. 1989 Oct 26;341(6244):705-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2677753 2677753]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Phillips, K.]]
+[[Category: Phillips K]]
-[[Category: Phillips, S E.V.]]
+[[Category: Phillips SEV]]
-[[Category: Rafferty, J B.]]
+[[Category: Rafferty JB]]
-[[Category: dna-binding regulatory protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:24:27 2008''

1cmb

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THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR

Structural highlights

Function

Evolutionary Conservation

See Also

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