3f2r
From Proteopedia
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==Crystal structure of human choline kinase alpha in complex with hemicholinium-3== | ==Crystal structure of human choline kinase alpha in complex with hemicholinium-3== | ||
| - | <StructureSection load='3f2r' size='340' side='right' caption='[[3f2r]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='3f2r' size='340' side='right'caption='[[3f2r]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3f2r]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3f2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2R FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC6:(2S,2S)-2,2-BIPHENYL-4,4-DIYLBIS(2-HYDROXY-4,4-DIMETHYLMORPHOLIN-4-IUM)'>HC6</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2r OCA], [https://pdbe.org/3f2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2r RCSB], [https://www.ebi.ac.uk/pdbsum/3f2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2r ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/3f2r_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/3f2r_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Choline kinase|Choline kinase]] | + | *[[Choline kinase 3D structures|Choline kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Hong | + | [[Category: Hong B]] |
| - | [[Category: MacKenzie | + | [[Category: MacKenzie F]] |
| - | [[Category: Park | + | [[Category: Park H]] |
| - | [[Category: Rabeh | + | [[Category: Rabeh WM]] |
| - | + | [[Category: Tempel W]] | |
| - | [[Category: Tempel | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal structure of human choline kinase alpha in complex with hemicholinium-3
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Bountra C | Edwards AM | Hong B | MacKenzie F | Park H | Rabeh WM | Tempel W | Weigelt J
