2qve

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==Crystal Structure of SgTAM bound to mechanism based inhibitor==
==Crystal Structure of SgTAM bound to mechanism based inhibitor==
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<StructureSection load='2qve' size='340' side='right' caption='[[2qve]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2qve' size='340' side='right'caption='[[2qve]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qve]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QVE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2qve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QVE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=247:(3R)-3-AMINO-2,2-DIFLUORO-3-(4-HYDROXYPHENYL)PROPANOIC+ACID'>247</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=247:(3R)-3-AMINO-2,2-DIFLUORO-3-(4-HYDROXYPHENYL)PROPANOIC+ACID'>247</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ohy|2ohy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qve OCA], [https://pdbe.org/2qve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qve RCSB], [https://www.ebi.ac.uk/pdbsum/2qve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qve ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qve OCA], [http://pdbe.org/2qve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qve RCSB], [http://www.ebi.ac.uk/pdbsum/2qve PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TAM_STRGL TAM_STRGL] Involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. Catalyzes the MIO-dependent deamination of L-tyrosine generating the corresponding alpha,beta-unsaturated acid, (S)-beta-tyrosine.<ref>PMID:12183628</ref> <ref>PMID:17516659</ref> <ref>PMID:20577998</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/2qve_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/2qve_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Aminomutase|Aminomutase]]
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*[[Aminomutase 3D structures|Aminomutase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces globisporus krasil'nikov 1941]]
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[[Category: Large Structures]]
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[[Category: Tyrosine 2,3-aminomutase]]
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[[Category: Streptomyces globisporus]]
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[[Category: Bruner, S D]]
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[[Category: Bruner SD]]
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[[Category: Christianson, C V]]
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[[Category: Christianson CV]]
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[[Category: Montavon, T J]]
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[[Category: Montavon TJ]]
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[[Category: Aminomutase]]
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[[Category: Enediyne]]
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[[Category: Mio]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of SgTAM bound to mechanism based inhibitor

PDB ID 2qve

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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