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1nde

From Proteopedia

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==Estrogen Receptor beta with Selective Triazine Modulator==
==Estrogen Receptor beta with Selective Triazine Modulator==
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<StructureSection load='1nde' size='340' side='right' caption='[[1nde]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1nde' size='340' side='right'caption='[[1nde]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NDE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NDE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [http://pdbe.org/1nde PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [http://www.ebi.ac.uk/pdbsum/1nde PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [https://pdbe.org/1nde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [https://www.ebi.ac.uk/pdbsum/1nde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nde ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1nde_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1nde_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Estrogen receptor|Estrogen receptor]]
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Consler, T G]]
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[[Category: Large Structures]]
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[[Category: Go, N]]
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[[Category: Consler TG]]
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[[Category: Hale, R L]]
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[[Category: Go N]]
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[[Category: Henke, B R]]
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[[Category: Hale RL]]
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[[Category: Hohman, D R]]
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[[Category: Henke BR]]
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[[Category: Jones, S A]]
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[[Category: Hohman DR]]
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[[Category: Lambert, M H]]
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[[Category: Jones SA]]
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[[Category: Lu, A T]]
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[[Category: Lambert MH]]
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[[Category: Moore, J T]]
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[[Category: Lu AT]]
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[[Category: Moore, L B]]
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[[Category: Moore JT]]
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[[Category: Orband-Miller, L A]]
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[[Category: Moore LB]]
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[[Category: Robinett, R G]]
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[[Category: Orband-Miller LA]]
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[[Category: Shearin, J]]
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[[Category: Robinett RG]]
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[[Category: Spearing, P K]]
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[[Category: Shearin J]]
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[[Category: Stewart, E L]]
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[[Category: Spearing PK]]
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[[Category: Turnbull, P S]]
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[[Category: Stewart EL]]
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[[Category: Weaver, S L]]
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[[Category: Turnbull PS]]
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[[Category: Williams, S P]]
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[[Category: Weaver SL]]
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[[Category: Wisely, G B]]
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[[Category: Williams SP]]
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[[Category: Er]]
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[[Category: Wisely GB]]
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[[Category: Erb]]
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[[Category: Estradiol]]
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[[Category: Estrogen]]
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[[Category: Estrogen receptor]]
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[[Category: Estrogen receptor beta]]
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[[Category: Oestrogen]]
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[[Category: Transcription]]
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[[Category: Triazine]]
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Current revision

Estrogen Receptor beta with Selective Triazine Modulator

PDB ID 1nde

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